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Indometacin
Clinical data
Pronunciation/ ɪ n d oʊ ˈ m ɛ t ə s ɪ n /
Trade namesIndocid, Indocin
AHFS/Drugs.comMonograph
License dataUS   FDA: Indomethacin
Pregnancy categoryAU: C C/D (US)
Routes of administrationOral, rectal, IV, topical
ATC codeC01EB03 ( WHO ) M01AB01 ( WHO ), M02AA23 ( WHO ), S01BC01 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability~100% (oral), 80–90% (rectal)
Protein binding99% [1]
MetabolismHepatic
Elimination half-life2.6-11.2 hours (adults), 12-28 hours (infants) [1]
ExcretionRenal (60%), fecal (33%)

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Taking more than you are told may raise your chance of very bad side effects. Do not take this medicine indomethacin suppositories for longer than you what are indomethacin pills used for told by your doctor.The concomitant use of indomethacin with other NSAIDs is not recommended due to the increased possibility of gastrointestinal toxicity, with little or no increase in efficacy.

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Prostaglandins are mediators of inflammation.OR.

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Y 22 hours I was feeling better, by 24 I was walking again, 26 hours I could stand in the shower.Have to stop taking it and go back to severe pain. I take 50 milligrams of indomethacin with a caffeine tab at first sign of migraine and call it quits until relief kicks in in about 1 1/2 hours.

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