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Conjugated estrogens
Estrone sulfate, the primary active component in conjugated estrogens (constitutes about 50 to 70% of total content).
Equilin sulfate, the second most major active component in conjugated estrogens (constitutes about 20 to 30% of total content).
Combination of
Estrone sulfateEstrogen
Equilin sulfateEstrogen
17α-Dihydro-equilin sulfateEstrogen
Clinical data
Trade namesCenestin, Enjuvia, Congest, C.E.S., Premarin, Prempro (with MPA), Premphase (with MPA), others
AHFS/Drugs.comConsumer Drug Information
Pregnancy categoryX
Routes of administrationBy mouth, topical, vaginal, intravenous injection, intramuscular injection [1] [2]
Drug classEstrogen
ATC codeG03CA57 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable [3]
Protein bindingHigh (to albumin and SHBG) [3] [1]
MetabolismLiver [3] [1]
Elimination half-lifeEstrone: 26.7 hours Estrone (BA): 14.8 hours Equilin: 11.4 hours [4]
ExcretionUrine [3]

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Premarin product names product:
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  2. Active substances: conjugated, estrogens
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Mg, or conjugated estrogens is administered in a daily premarin for face of 0.Local premarin for face is for women who are only suffering from vaginal dryness, according to the ACOG. The ACOG also recommends that women who do chose to use HRT use the lowest effective dose for the shortest possible amount of time.

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Symptoms of overdose may include: severe nausea/vomiting, unusual vaginal bleeding.There are prescription free over-the-counter treatments for hot flashes, vaginal dryness and other menopausal symptoms. Thank you.

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Mg/day total has been found to suppress total testosterone levels in men to an equivalent extent as 3 mg/day oral diethylstilbestrol, which is the minimum dosage of diethylstilbestrol required to consistently suppress total testosterone premarin fors face into the castrate range 50 ng/dL 45 CEEs are hydrolyzed in the premarin fors face during first-pass metabolism upon oral administration.The risk of haemorrhagic stroke is not increased during use of HRT.

This relative risk is not dependent on age or on duration of use, but as the baseline risk is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age, see section 4.

HI studies combined - Additional risk of ischaemic stroke* over 5 years' use no differentiation was made between ischaemic and haemorrhagic stroke.

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Due to the low level of absolute risk in younger premarin fors face, however, the balance of benefits and risks for these women may be more favourable than in older women.Do not use premarin fors face, with or without progestins, to prevent heart disease, heart attacks, strokes or dementia decline in brain function Using estrogen-alone may increase your chances of getting strokes or blood clots.

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

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Make a note of key personal information. Include any major stresses or recent life changes.There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens 5.

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The WHI estrogen plus progestin substudy reported increased risks of invasive breast cancer 5. The WHIMS estrogen plus progestin ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older 5.1996.

Postmenopausal estrogen and progestin use and the risk of cardiovascular disease.

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