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mg TID x 7 days500 mg BID x 7 daysSaquinavir soft gel caps AUC: increased 177% Cmax: increased 187 saquinavir hard gel caps AUC: increased 500% larithromycin AUC: increased 45% Cmax: increased 39% 14-hydrooxyclarithromycin AUC: decreased 24% Cmax: decreased 34% Inhibition of CYP450 3A4 by clarithromycin Dose adjustment not established Stavudine275500 mg BID clarithromycin infusion 200 mg ritonavir BID500 mg BID x 25 dosesTipranavir AUC: increased 66% Cmax: increased 40% Cmin: increased 100% larithromycin AUC: increased 19% Cmax: no clarithromycin infusion change; Cmin: increased 68% clarithromycin infusion AUC: decreased 97% Cmax: decreased 97% Cmin: decreased 95% ncreased tipranavir clarithromycin infusions possible decreased clarithromycin effectsInhibition of CYP450 3A4 by clarithromycin; induction of CYP450 3A4 by tipranavir No dose adjustment necessary Zidovudine358, 81-500 mg BIDZidovudine Cmax: increased 50% AUC: no significant change--- No dose adjustment necessary "-" indicates that there are no data availableStaphylococcus aureus, Bacillus cereus, Bordetella pertussis, Chlamydia trachomatis, Corynebacterium diphtheriae, Gardnerella vaginalis, influenzae, Legionella pneumophila, Moraxella catarrhalis, Mycobacterium spp.

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Specifically, we evaluated pulmonary histopathological inflammation, bronchoalveolar lavage BAL cytokine/chemokine/growth factor concentrations, airway hyperresponsiveness and quantitative BAL M. pneumoniae culture during the clarithromycin infusion of treatment with increasing dosages of clarithromycin.

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