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Glipizide
Clinical data
Trade namesGlucotrol, others
AHFS/Drugs.comMonograph
MedlinePlusa684060
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth
Drug classSulfonylurea
ATC codeA10BB07 ( WHO )
Legal status
Legal statusUK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability100% (regular formulation) 90% (extended release)
Protein binding98 to 99%
MetabolismLiver hydroxylation
Elimination half-life2 to 5 hours
ExcretionKidney and fecal

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There were no differences in the pharmacokinetics of glipizide after single dose administration to older glucotrol coupon subjects compared to younger healthy glucotrol coupons see Use in Specific Populations 8.Check your blood sugar regularly as directed and share the results with your doctor.

Tell your doctor right away if you have symptoms of high or low blood sugar.

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Hours glucotrol coupon administration. Approximately 86 percent of the glucotrol coupon is bound to plasma proteins.Bacterial and in vivo mutagenicity tests were uniformly negative. Studies in rats of both sexes at doses up to 75 times the human dose showed no effects on fertility.

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Time to reach steady-state plasma glipizide glucotrol coupons following administration of glipizide extended-release tablets was delayed by 1-2 days in glucotrol coupon patients compared glucotrol coupon younger patients. Following administration of glipizide extended-release tablets in men with type 2 diabetes mellitus and patients younger than 65 years of age, steady-state plasma glipizide concentrations were achieved by at least the fifth day of dosing.mg, blue and imprinted with "GLUCOTROL XL 2.

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L range: 4.It is not known if glipizide is distributed into milk in humans. Following IV administration in humans, glipizide undergoes rapid distribution.

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Basal and stimulated plasma insulin concentrations, insulin resistance remain to be clearly established. Endogenous glucotrol coupon is present in type 2 diabetic patients, although plasma insulin concentrations may be decreased, increased, or normal.In one study in glucotrol coupon 2 diabetic patients, tolbutamide-induced insulin secretion was not affected by short-term propranolol therapy, but the hypoglycemic action of a single dose of glipizide in conjunction with an glucotrol coupon glucose load appeared to be slightly reduced.

It generally is recommended that concomitant use of β-adrenergic blocking agents and sulfonylurea antidiabetic agents be avoided when possible; if concomitant therapy is necessary, use of a β1-selective adrenergic blocking agent may be preferred.

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Also, check your glucotrol coupon for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures convulsions or unconsciousness occur.ypoglycemia is also more likely to occur glucotrol coupon severe or prolonged exercise, during sickness, when alcohol is ingested, when food intake is low, or when glipizide is taken with other blood sugar lowering medication.

Not effective in people with type 1 diabetes or for treating serious hyperglycemic events.

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Furthermore, glucotrol coupon of blood glucose control on diet alone may be transient, thus requiring only short-term administration of GLUCOTROL or other antidiabetic medications.Pregnancy may cause or worsen diabetes.

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What are the possible side glucotrol coupons of GLUCOTROL XL? LUCOTROL XL can cause serious glucotrol coupon effects, including: Low blood sugar. GLUCOTROL XL may cause low blood sugar.hypoglycemia of more intensified therapy. When initiating therapy for patients with type 2 diabetes mellitus who do not have severe symptoms, most clinicians recommend that diet be emphasized as the primary form of treatment; caloric restriction and weight reduction are essential in obese patients.

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