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Isotretinoin
Clinical data
PronunciationSee note at tretinoin
Trade namesAccutane (originator), others [1]
AHFS/Drugs.comMonograph
MedlinePlusa681043
License dataUS   FDA: Isotretinoin
Pregnancy categoryAU: X (High risk) US: X (Contraindicated)
Routes of administrationBy mouth, topical
ATC codeD10AD04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityVariable
Protein binding99.9%
MetabolismHepatic
Elimination half-life10–20 hours
ExcretionRenal and fecal

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Concurrent administration of isotretinoin with topical keratolytic or exfoliative anti-acne agents should be avoided as local irritation may increase see section 4. Patients should be is amnesteem the same as accutane to use a skin moisturising ointment or cream and a lip balm from the start of treatment as isotretinoin is likely to cause dryness of the skin and lips.If the test is positive, you must stop taking this medication and consult your doctor right away.

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