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| Clinical data | |
|---|---|
| Trade names | Femara, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a698004 |
| License data | US FDA: Letrozole |
| Pregnancy category | US: D (Evidence of risk) |
| Routes of administration | By mouth (tablets) |
| Drug class | Aromatase inhibitor; Antiestrogen |
| ATC code | L02BG04 ( WHO ) |
| Legal status | |
| Legal status | CA : Schedule VII UK: POM (Prescription only) US: ℞-only |
| Pharmacokinetic data | |
| Bioavailability | 99.9% |
| Protein binding | 60%, mainly to albumin |
| Metabolism | pharmacologically-inactive carbinol metabolite (4,4΄-methanol-bisbenzonitrile) [1] |
| Elimination half-life | 2 days [1] |
| Excretion | Kidneys [1] |
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One negative side effect that some women experience is the thinning of the endometrium, or the letrozole buy uk lining of the uterus, that is seen with repeated Clomid use.months from trial entry to beginning of chemotherapy Delaying chemotherapy and its coincident side effects is likely to result in a better quality of life for patients.
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