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There was a therapeutic effect at 20 mg/day, but higher doses 40 or 60 mg/day showed a higher response rate. A small number of children, teenagers, and young adults up to 24 years of age who took antidepressants 'mood elevators' such as fluoxetine during clinical ... This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
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Extrapyramidal reactions, including acute dystonic reactions, torticollis, dyskinesia including buccolingual and buccoglossal syndrome hypertonia, and akathisia, have occurred in 1% or less of patients receiving fluoxetine. An extrapyramidal reaction consisting of torticollis, jaw rigidity, cogwheel rigidity, and loss of fluid motion in gait reportedly occurred in one patient several days after initiation of fluoxetine therapy, but responded rapidly to an anticholinergic antiparkinsonian agent i.Fluoxetine.
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These studies were of 12 weeks' duration and used a flexible dosing schedule. Fluoxetine therapy in both studies was initiated in a dosage of 10 mg daily for the first week and then the dosage was escalated to 20-60 mg daily depending on clinical response and tolerability.Fluoxetine hydrochloride appears to be well absorbed from the GI tract following oral administration.
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Higher average steady-state fluoxetine and norfluoxetine concentrations were observed in children relative to adults; however, these concentrations were within the range of concentrations observed in the adult population. As in adults, fluoxetine and norfluoxetine accumulated extensively following multiple oral dosing; steady-state concentrations were achieved within 3 to 4 weeks of daily dosing.Obesity.
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