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Also, your acne may seem to get worse before it gets better.Sci Rep. 2018 May. 8434. Medline.

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Month 3: I increased frequency of application to 3 nights a week still waiting after washing my face and avoiding areas with thinner more sensitive skin.Efficacy at reduced frequencies of application has not been established.

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Tretinoin has been reported to cause severe irritation on eczematous skin and should be tretinoin cream usp 0 1 with utmost caution in patients with this In a life-time dermal study in CD-1 mice with another tretinoin cream, at 100 and 200 times the average recommended human topical clinical dose, a few skin tumors in the female mice and liver tumors in male mice were observed.

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